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They'll be energized, while at home against a tough division rival, and will sneak out another close win. Weinfuss' pick: Cardinals 20, Bengals 17 Pick NFL winners straight up or against the spread and compete to win more than $14,400 in prizes! Stat to know: Geno Smith has a 77.3 completion percentage this season, the highest by any QB through a team's first four games of a season in NFL history (min. Sure, the Packers have found replacements for all three, but those were big-time players who performed in the clutch. Vikings 27, Bears 26 -- Jeff Dickerson, Cowboys' running game will be tested on Sunday (1:06), Week 5 NFL predictions: Scores for every game, Dolphins' Jaelan Phillips, teammates inspired by mentoring incarcerated teens, What adding Odell Beckham Jr. would mean for the New York Jets, Extending Vikings star Justin Jefferson: what it could cost, possible sticking points. Wagoner's pick: 49ers 27, Browns 24 Read more. The team that gets the running game going will have a decisive advantage. Here are some lines that could change after this week's slate concludes. There will be 259 total selections over a three-day period . Read more. Moody's pick: Eagles 30, Cardinals 17 More NFL coverage , Bold prediction: The Bucs will hold Alvin Kamara under 100 all-purpose yards and under 45 rushing yards. But the Commanders' run defense will be severely tested by Tennessee running back Derrick Henry. The Cowboys will want to prove last week was more of a fluke than a trend. -- Turron Davenport. Jets 20, Browns 17 -- Rich Cimini, Old friend Josh McCown is healthy and completing 70 percent of his passes, and the Jets have won two in a row with the kind of run-pass balance that the Browns should study. -- Jeff Legwold. Tyrod Taylor has excelled in passing to Charles Clay and LeSean McCoy this season, but the Bengals boast the NFL's lowest yards per catch (6.49) by opposing tight ends and running backs. See Week 5 rankings. But New York also hasn't faced a quarterback like Rodgers and has a pedestrian 9.0 sacks and a 29.0% pressure rate, per NFL Next Gen Stats. On the flip side, the Packers might have to run the ball with Aaron Jones given the turf toe injury to Davante Adams, who caught two touchdown passes in the previous meeting in Dallas. NFL odds, Vegas lines, picks, spreads, bets, predictions for Week 5 FPI prediction: KC, 80.9% (by an average of 12.0 points), Matchup must-reads: Mahomes, Favre and other NFL stars reveal the larger-than-life tales behind Andy Reid Colts GM Chris Ballard has needed his no-flinch, no-panic approach Chiefs RB Williams has waited behind big-name backs before Ebron 'disgusted' by drops, takes blame for Colts' loss, Monday, 8:15 p.m. The Week 5 NFL schedule for the 2022 season is stacked with great matchups, and we have you covered with what you need to know heading into the weekend. play. The Bills and Steelers matchup, discussed in greater detail below, moved from Buffalo minus-8 to Buffalo minus-14, but a perhaps. Betting nugget: Arizona is 19-9 ATS in September/October under Kliff Kingsbury (12-3 ATS in October). Week 5 NFL predictions: Scores for every game - ESPN The Saints' problems are beyond the quarterback right now, as they are among the worst teams in the league in both penalties and turnover differential. NFL schedule 2021: Week 5 picks, odds, predictions, best - SportsLine Another one of its Week 5 NFL predictions: The Packers (-3) cover on the road against the Bengals in a matchup of 3-1 teams. Betting nugget: Both times Rodgers faced the Cowboys in Dallas, Green Bay won the game outright as an underdog (2016 divisional round and 2017 Week 5). It sounds crazy, but the Jets will win their third straight game. They have the NFL's second-ranked rushing defense, surrendering only 59.3 yards per game, and they held Christian McCaffrey to just 37 rushing yards in Week 2 (53 all-purpose yards) and the Rams to just 28 total rushing yards in Week 4. Chuck Pagano has never started a season 1-4 as coach of the Colts. After catching eight passes for 111 yards in the season opener, he has not reached 70 receiving yards in any of the past three games. See Week 5 rankings. What to know for fantasy: T.J. Hockenson had 24.2 fantasy points through three weeks before exploding for a career-best 39.9 points last week against the Seahawks. Stat to know: JuJu Smith-Schuster's 15 receiving yards against the Bengals were the fewest he has had in a regular-season game in which he registered at least one reception. But its not like Rodgers needs time to get ready to face a Rod Marinelli-coached defense. Jets 24, Browns 10 -- Pat McManamon, The Lions are strong against the run, which makes the timing of Panthers quarterback Cam Newton finding his timing against New England most important. Stat to know: Jacoby Brissett is fifth in both QBR (75) and completion percentage (74%) in home games this season. NFL draft 2023: Biggest post-draft questions for all 32 teams - ESPN Experts weigh in with analysis and provide premium picks for upcoming NFL games. That'll help the Texans continue their eight-game winning streak over the Jaguars. -- Todd Archer, Bold prediction: The first team to 30 rushing attempts will win. All-Time Longhorns NFL Draft Picks. -- Jordan Raanan. Bold prediction: With quarterback Sam Darnold (mono) sidelined for a third straight game, the Jets' epic struggles on offense will continue. FPI prediction: GB, 86.9% (by an average of 13.5 points), Matchup must-reads: How Saquon Barkley and AJ Dillon became the 'Quad Kings' of the NFL Landon Collins, Giants finalizing deal, sources say Packers' Aaron Rodgers wanted longer London trip Rodgers: 'This way of winning, I don't think, is sustainable', What to know for NFL Week 5: Score picks, bold predictions, fantasy tips, key stats for all 15 games, Which NFL teams still have roster holes? The Saints, meanwhile, have committed an NFL-high 11 turnovers -- including five interceptions in three games from Jameis Winston -- so the opportunity will be there. NFL Nation reporters give their picks for Week 5, including whether the Cowboys can bounce back against Aaron Rodgers and the Packers. FPI prediction: PHI, 75.9% (by an average of 9.7 points), Matchup must-reads: Jalen Ramsey to the Eagles: What are the realistic odds? These two teams played last year in similar circumstances, with the Titans leaving with the victory due to Mariota's four touchdowns and a stout running game. They've gone 21 straight possessions without a score, and that number will reach the high 20s. Chicago knows how dangerous Minnesota's run game can be, so they'll stack the box to try to take away Dalvin Cook and make Cousins beat them with his arm. NFL: Mahomes favorite for game's MVP NFL picks, predictions for Week 5 Los Angeles Rams (-1.5) at Seattle Seahawks Thursday, 8:20 p.m., FOX/NFL Network The NFC West grinder continues. Since Alex Smith got injured in Week 11 of last season, it has had an NFL-high five starting QBs. When the draft ended, there was a total of 43 trades, breaking . The Bengals are allowing 8.6 yards per attempt, which is ideal for a team averaging 5.5 despite having Kyler Murray -- who has thrown for 300 yards in two of his first four games. Depth charts for every team FPI prediction: ARI, 56.4% (by an average of 1.8 points), Matchup must-reads: Miles Sanders' emergence makes the Eagles so much better Defense keeps Cardinals afloat while offense figures it out, What to watch for: Matthew Stafford has been sacked 16 times this season, which is tied for the second most in the NFL. ET | ESPN/ESPN App Everything you want to know is here in one spot to help you get ready for a loaded weekend of NFL football. As Giants defensive coordinator Wink Martindale said of the Packers QB, 'It's like owning a python and saying, 'Don't worry about it, he won't bite.'" It won't hold, though, as J.J. Watt & Co. make life miserable for the Falcons' offensive line. Betting nugget: Washington has failed to cover in three straight games. ET | Fox Big Ben's 3-1 home-away touchdown ratio since 2015 looms large here, especially with Bell looking like his 2016 self and Jacksonville entering the week allowing 5.7 yards per carry, the league's worst by a large margin. FPI prediction: CAR, 56.2% (by an average of 1.8 points), Matchup must-reads: Jimmie Ward year away from being among rarefied 49ers company Mayfield struggles, but Panthers don't have another option Nick Bosa says 49ers' defense has personnel to be 'best in the league' Mayfield takes blame for offense's struggles amid 1-3 start Darnold's return from IR not close, coach Matt Rhule says, 4:25 p.m. Read more. The 2023 NFL draft wrapped up Saturday and through five rounds, 12 quarterbacks were selected -- the most in the common draft era. Bengals 13, Bills 9 -- Mike Rodak, The Bengals have a tough matchup against one of the league's best defenses (Buffalo is 10th overall), but it looks like their offense finally has begun to click in the past two weeks. ET Thursday after a few more conversations with people around the NFL. Given the Colts' struggles protecting the quarterback (they've allowed 14 sacks, tied for fifth most in the league) and the Niners' ability to take advantage of porous offensive lines (nine sacks total against Seattle and Arizona), this would seem to be the type of game the 49ers can win. The Steelers have allowed three touchdowns on passes that have traveled at least 25 yards in the air, tied for third worst in the NFL. -- Courtney Cronin. Giants 24, Chargers 23 -- Jordan Raanan, The Cardinals are 0-2 this season against NFC teams not in their division, but the biggest question mark will be whether the Cardinals can keep Carson Palmer on his feet. Read more. 1 in both defensive efficiency and QBR allowed in that span. McManus's pick: Eagles 30, Jets 17 (1:06). Read more. San Francisco 49ers Coach Kyle Shanahan, right, talks with quarterback Trey Lance during a Week 4 loss . Raiders hoping to reverse London trend by changing travel schedule Left with no defense, Jackson needs to carry Ravens this season, 1 p.m. But theyll defeat him as they have other young quarterbacks except for Oaklands Derek Carr as a rookie in 2014. -- Rob Demovsky. Overall, Minnesota is tied for eighth in points allowed (19.0) and third in rushing yards allowed (71.3). Reiss' pick: Patriots 30, Redskins 6 -- DJ Bien-Aime. -- Paul Gutierrez. Stat to know: The Vikings have allowed at least 300 yards in 12 straight games dating back to last season. -- Jenna Laine, Bold prediction: The Falcons, with no Cordarrelle Patterson and against a good run defense, will manage to once again top 150 rushing yards with Tyler Allgeier leading the way. No, Williams isn't the greatest running back of all time -- or possibly even the best overall on his team -- but he has proven to be consistent and durable behind a strong offensive line. Matchup rating: 9.9 | Spread: CIN -3 (46.5), What to watch for: The game between winless teams could feature multiple sacks. I tweaked my predictions from Sunday to reflect . Patrick Mahomes has been as good against the Raiders as any opponent, with a 7-1 record, 22 touchdowns and just three interceptions. Barshop's pick: Texans 20, Falcons 17 While the Chargers' running game has struggled, Herbert will always be a threat in the passing game. See Week 5 rankings. 2023 NFL draft buzz: McShay on top prospects, QBs, early picks - ESPN Read more. The Chiefs' offense is a complete running and passing groove with Patrick Mahomes. Spread: GB -8.0 (41), What to watch for: This could be a nightmare matchup for the Packers' defense. Matchup rating: 42.5 | Spread: MIN -5.5 (43.5), What to watch for: How will Kirk Cousins perform vs. the Giants' 25th-ranked pass defense, which is allowing 279.5 yards per game. This feels like it could go either way, but the edge goes to the home team. Read more. FPI prediction: NO, 72.6% (by an average of 6.9 points), Matchup must-reads: The Seahawks have needed every bit of Geno Smith's unlikely success Andy Dalton gave Saints' offense a spark, but bigger issues loom after 1-3 start Saints' Alvin Kamara (rib) expects to play against Seahawks, What to watch for: Washington has done a nice job stopping the run the past two weeks against the Eagles and Cowboys, allowing an NFL-best 2.27 yards per carry and tying for second at 67 yards allowed during that stretch. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates . And the Washington passing attack? Read more. NFL Power Rankings Week 5 bet now, bet later Week 5 spot bets Under 50.5 (-110) Combined, both teams have begun the season 3-5 O/U while the Bengals are riding a three-game Under. Read more. NFL best bets and picks for Week 5: Take the 49ers and the points, and the Jets-Falcons over. What to know for fantasy: Darnell Mooney hauled in 17 of 25 targets for 183 yards when playing the Vikings last season. Their offense is clicking on all cylinders, and their defense finally showed signs of life in the second half Sunday, holding Dallas to a mere six points. Tennessee adopted a quick-hitting passing attack last week to speed up Mariota's decision-making, which should be the way to go against a Bills defense that takes away the vertical passing game and is third in the league in allowing a 57.1 completion percentage. He has had 11 passes batted down at the line of scrimmage, six more than any quarterback in the NFL this season. MIN-NYG | NYJ-PHI | JAX-CAR Levis opens up about draft day Eli Manning beats Philip Rivers for the first time in his career. The offense remains a question mark, however, and could be without starting left tackle Rees Odhiambo because of a chest injury. -- Mike DiRocco, Bold prediction: Texans wideout Brandin Cooks will have his best outing of the season with a 100-yard game. The Steelers' 2022 quarterback journey, and what happens next, What to watch for: The Patriots have given up 325 rushing yards on 51 carries (6.37 on average) over their past six quarters, while the Lions rank first in the NFL in average yards per rush (5.9) and sixth in total rushing yards per game (164). Read more. They haven't lost three straight road games since 2018. Irrelevant' pick on Toledo's Johnson, Chargers go all-in on TCU with Duggan pick in 7th, 10 fantasy football breakout players for 2023, Will Levis opens up about emotional draft day, Steelers' first draft under Omar Khan was 'aggressive' and achieved high marks, After hoopla of going No. Thus, breaking the streak won't be easy for the Ravens. His 43.1 QBR this season is also his worst through the first four games in that same time frame. We answered the biggest post-draft question for all 32, LB Barrett's 2-year-old daughter drowns in pool, Deion 'ashamed' after only 1 HBCU player drafted, Sources: NFL eyes May 11 to release schedule, Teams set NFL record with 43 trades during draft, Jets coach Saleh: Rodgers making 'presence felt', Cowboys scout emotional as team drafts his son, Rams use 'Mr. ET | FOX Spread: NE -3.0 (45.5). They'll do just enough to keep things that way. Game of Midweek: Colts at Broncos (-3.5, 44 o/u) . They also rank No. 3 all-time rusher Barry Sanders, 1 p.m. Full list of Mr. Irrelevants in NFL draft history: Is Brock Purdy already the best final pick? . Since Chicago isnt a huge threat with its receivers, the defense will focus on Tarik Cohen and Jordan Howard in the running game. 2023 NFL Draft Index - University of Texas Athletics Washington opened the. But the key in this one will be the ability of the Carolina defense to make the Lions one-dimensional and force Matthew Stafford to beat them. -- Jenna Laine. See Week 5 rankings. Stat to know: The Rams have been outscored 44-3 with an NFL-worst minus-41 point differential in the fourth quarter this season -- they have outscored opponents by 17 in the first three quarters. FPI prediction: LA, 65.1% (by an average of 4.7 points), Matchup must-reads: Jerry Jones: An 'injustice' not to give coach McCarthy credit Police report filed in Wagner tackle Cowboys D reaching elite levels of legendary Doomsday Defense? -- John Keim, Bold prediction: Titans quarterback Ryan Tannehill will finish with 300 passing yards in a win over the Commanders. Finally, Seth Walder and Eric Moody give us final score picks for every game. Russell Wilson's QBR in five road games against the Rams is 48.6 compared with 71.5 in his 37 other road games. What to know for fantasy: Curtis Samuel's target share is nearly twice that of DJ Moore (24.1% to 12.1%) with Kyle Allen under center for the Panthers this season. What to know for fantasy: Broncos receiver Courtland Sutton is on pace for 88 catches, 1,236 receiving yards and eight touchdowns. ARI-CIN | DEN-LAC | GB-DAL -- Mike Reiss, Bold prediction: Lions running back Jamaal Williams will rush for at least two touchdowns. San Francisco's defense had seven sacks and 17 quarterback pressures on Monday night against the Rams. Through four games, Kupp has been targeted 54 times with 42 catches for 402 yards. However, Indianapolis figures to be rocking as Peyton Manning is honored with a statue, and mobile signal-callers like Jacoby Brissett have helped mitigate some of San Francisco's pass-rush ability. The latest hint that the Jets are destined for the spotlight came from ESPN's Adam Schefter. 1, Panthers' Bryce Young is all 'business now', Top picks Christian Gonzalez, Keion White reflect Patriots' ideal identity, Big takeaways from the NFL draft: A historic QB class, the rebuilt AFC South and new GMs thriving, NFL Nation sizes up all 259 draft selections, XFL semifinals: Defenders roll Sea Dragons, set up title showdown with Renegades. Click on each game for the game preview and CFN Prediction Week 5 NFL Expert Picks Expect the Raiders' overachieving defense to make a play or two -- paging Khalil Mack and his four sacks -- to jump-start the offense, and all will be right in Silver and Blackdom for a week, at least. The Saints quarterback is remarkably 2-0 as Drew Brees' replacement, but he has thrown for an average of only 185 yards per game in those two starts. -- Jake Trotter, Bold prediction: The Chargers have yet to put together a 100-rushing yard performance this season, but that will change Sunday against the Browns. What to know for fantasy: Dallas' Amari Cooper is on pace for a career-high 84 catches and has scored four times in four games this season. 1 overall pick, are hours away from being on the clock -- which means the 2023 NFL draft has arrived. But Trubisky is making his first career start on Monday Night Football. How have point spreads moved for Week 5 as Sunday approaches? Stat to know: Texans edge rusher Whitney Mercilus now has four straight games with a sack, tied for the longest active streak in the NFL with Clay Matthews and Shaquil Barrett. Justin Fields is 3-9 ATS as an underdog. Indianapolis' offensive efficiency might be a good match for Kansas City's offensive power. What to know for fantasy: After scoring 11 times in his first 14 games last season, Hopkins has scored just twice in his past seven games (playoffs included). -- Mike Wells. Swift likely out again vs. Patriots, source says, What to watch for: The Vikings' defense has given up 1,054 passing yards this season, seventh-most in the NFL, as it meanders through the adjustment process to coordinator Ed Donatell's 3-4 scheme. These two teams just played each other in the regular season finale last week when the Roughnecks won 25-9 despite Brandon Silvers, Max Borghi, Deontay Burnett, and Brycen Alleyne all sitting. They might miss them Sunday. Stat to know: Brady's only three-game losing streak in his career came from Weeks 4 to 8 in 2002, his second season as a starter. -- Eric D. Williams, Bold prediction: The Broncos have not intercepted a pass this season, but they will get their first one Sunday.

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