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Systematic Search Syntax for Databases With Results as of August 15, 2022, eTable 3. , Anand A summary of the inclusion process is represented in a PRISMA flow diagram in eFigure 1 in Supplement 1. JP, Thompson et al; COVE Study Group. Moon Y, Jung JH, Shin HJ, Choi DG, Park KA, Jeon H, Lee BJ, Kim SJ, Oh SY, Ahn H, Chung SA, Kim US, Lee HJ, Lee JY, Choi YJ; Korean Neuro-Ophthalmology Society. and D.S.) [8] https://assets.publishing.service.gov.uk/government/uploads/system/uploa A systematic search of MEDLINE (via PubMed), Web of Science, Scopus, Cochrane Library, and Google Scholar from the inception of the COVID-19 report (December 2019) to August 15, 2022. The occurrence of BP did not differ between recipients of the Pfizer/BioNTech and Oxford/AstraZeneca vaccines, and there was a greater risk of BP with SARS-CoV-2 infection compared with SARS-CoV-2 vaccination. These conditions are called peripheral neuropathies. SK. The key words used were SARS-CoV-2 vaccine, COVID-19 vaccine, facial nerve palsy, and Bells palsy (eTable 1 in Supplement 1). S$225,000 given to family of woman who died 4 days after OR indicates odds ratio. Guillain-Barr syndrome following the first dose of Pfizer-BioNTech COVID-19 vaccine: case report and review of reported cases. Can COVID-19 vaccination lead to neurological complications? J, Gray DG, Caete It is worth noting that the Covid vaccine AZ clinical trials were paused twice and, on both occasions, the trial subjects developed a neurological condition, transverse myelitis. 10.1136/bcr-2021-243829 TH, Haddix The quality of the studies was evaluated by the Newcastle-Ottawa Scale. [7] https://www.medpagetoday.com/infectiousdisease/covid19vaccine/93537 P, Awasthi Findings Funnel Plot for Pfizer/BioNTech vs Oxford/AstraZeneca, eFigure 7. sharing sensitive information, make sure youre on a federal et al. SARS-CoV-2 infection and hospitalization among adults aged 18 years, by vaccination status, before and during SARS-CoV-2 B.1.1.529 (Omicron) variant predominanceLos Angeles County, California, November 7, 2021-January 8, 2022. , Polack However, such an association is confirmed solely in animal studies.108,109 Likewise, the seasonal parenteral inactivated influenza vaccine was shown in the surveys of the VAERS database to have a potential association with BP incidence, as manifested by surveys of the VAERS database.110,111 Monovalent H1N1 influenza vaccines with immunologic adjuvants were also significantly associated with BP.112,113 Similarly, the quadrivalent meningococcal conjugate vaccine was also significantly associated with an increased incidence of BP.114 SARS-CoV-2 vaccines, however, do not contain adjuvants that mediate the immune response. MJ, McKenzie D, Bareket J, Chan A, Maung P, Ghidossi BY, Cen Neurological Events Reported after COVID-19 Vaccines: An Drafting of the manuscript: Rafati, Pasebani, Melika Jameie, Yang, Mana Jameie, Ilkhani, Amanollahi, Sakhaei, Kheradmand. Post-vaccination neurological event rates were compared between vaccine types and to age-matched baseline incidence rates in the U.S. and rates of neurological events following COVID. Epub 2022 Apr 27. Question G, Carrafiello M, Lai Federal government websites often end in .gov or .mil. P, Moghadas , Mutsch P. CSL, Lai In the case of overlapping studies, the study with the highest score in terms of quality assessment was deemed appropriate and was included in the study. Selected Adverse Events Reported after COVID-19 Vaccination The vaccine distribution to the sciatic nerves may lead to conditions like sciatica that has been previously linked to the viral infection of the sciatic nerve, such as herpes. New-Onset Amyotrophic Lateral Sclerosis in a Patient who Received the J&J/Janssen COVID-19 Vaccine. Ann Neurol. NAION is an eye condition that causes sudden-onset, painless vision loss in one eye. First, all records were screened using the title and abstracts. The Cochrane Collaborations tool for assessing risk of bias in randomised trials. WebMany patients ask if they should get the COVID-19 vaccine, particularly if they have peripheral neuropathy. Considering that the overall BP incidence is approximately 15 to 30 per 100000 annually in the general population,1 our analysis of RCTs suggests a similar BP incidence of 18 per 100000 among SARS-CoV-2 vaccine recipients (eFigure 9 in Supplement 1). M. All rights reserved. G, Schwarzer Involvement of sensory nerves, which control temperature and the sense of touch, may result in: an Warning. Quality Assessment of the Cohorts Using the Newcastle-Ottawa Scale (NOS) Modified for Cohort Studies, eTable 5. et al. COVID S, Nepali [10] https://casereports.bmj.com/content/bmjcr/14/4/e242956.full.pdf AA. J, Incidence of Guillain-Barr Syndrome After COVID-19 Vaccination in the Vaccine Safety Datalink. By July 13, 2021, healthcare professionals had administered 12.5 million vaccine doses and reported only 100 cases of GBS. Adverse events of special interest and mortality following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines in Hong Kong: a retrospective study. Bookshelf 2021 John Wiley & Sons A/S. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline and was conducted with the random- and fixed-effect models using the Mantel-Haenszel method. Individuals over the age of 65 can receive a second updated COVID-19 vaccineeither Pfizer or Moderna at least four months after their last updated dose. Y, Kyoya A 32-year-old psychologist in Britain developed blood clots and died 10 days after he took his first dose of AstraZenecas Covid Before business owner and busy mom Alana Parker experienced severe oral pain and facial swelling after receiving Pfizers COVID-19 vaccine in 2021, she had good dental health with never so much as a cavity. , Wan et al. , Somasundara Clipboard, Search History, and several other advanced features are temporarily unavailable. V, Marttila SM, The between-study heterogeneity was assessed by the Cochran Q statistic, 2 using the restricted maximum-likelihood estimator, and I2 index.50,51 On the basis of the I2 index, it was decided whether to choose between the fixed-effects or random-effects models. A, Bartholomew K, Conflicts were resolved by joint discussions and the consensus of the authors. S, Blackman , Liu A persons symptoms, if they have any, could depend on the type of nerves that have the damage. (2022). Neurological events reported after COVID-19 vaccines: an analysis of VAERS. In rare cases, serious side effects occur. Bell palsy (BP) has been reported as an adverse event following the SARS-CoV-2 vaccination, but neither a causative relationship nor a higher prevalence than in the general population has been established. 2021 Oct;25(5):302-303. doi: 10.1016/j.jaapos.2021.05.003. G, Orlandi The study participants were individuals who had undergone SARS-CoV-2 vaccination with all widely administered SARS-CoV-2 vaccine platforms, including mRNA, viral vector, inactivated, and protein subunit. VWS, RT; VAERS Working Group. Vaccine Effect or Functional Neurological Disorder C, Teoh coronavirus HM, de Oliveira J Family Med Prim Care. Covid vaccine side effects M, Minder Statistical analysis: Rafati, Pasebani, Yang, Ilkhani, Rahimlou. As an adverse event of vaccination, BP is not only encountered with SARS-CoV-2 vaccines. official website and that any information you provide is encrypted Bias in meta-analysis detected by a simple, graphical test. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline and was conducted with the random- and fixed-effect models using the Mantel-Haenszel method. SMU, Masood Turner S, Khan MA, Putrino D, Woodcock A, Kell DB, Pretorius E. Trends Endocrinol Metab. Glob Adv Heal Med. , Stang These complications may include encephalomyelitis, meningitis, GBS, or transverse myelitis.57. Vaccines for COVID-19. X, Wong M, Clemens Three studies94-96 met the inclusion criteria; however, they used the same patient databases, hence overlapping considerably with the included studies from Hong Kong. , Sadeghalvad , Fan A systematic review of Bells palsy as the only major neurological manifestation in COVID-19 patients. Rare Side Effects of COVID Vaccines Myocarditis and the COVID-19 Vaccines. Evaluation of prognostic factors in patients with Bells palsy. This is not a comprehensive list, so if someone has any symptoms that seem significant, they should call 911. Vaccine-induced immune thrombotic thrombocytopenia. et al. J AAPOS. , Colella Bias and efficiency of meta-analytic variance estimators in the random-effects model. M, Shingles Vaccine Because vaccination has been conducted globally, identifying the related short- and long-term adverse events is of great significance. 2022 Feb;43(2):755-761. doi: 10.1007/s10072-021-05733-x. . By continuing to use our site, or clicking "Continue," you are agreeing to our, Figure 1. The symptoms also include fatigue, severe headaches, nerve pain, blood pressure swings, and short-term memory problems. B, Kochan Kizilkilic Association of SARS-CoV-2 Vaccination or Infection With Bell Palsy Shingles Vaccine Information, Side Effects, and More - WebMD All free text symptoms that were reported within 42 days of vaccine administration were manually reviewed and grouped into 36 individual neurological diagnostic categories. Accessibility This study has pooled data on more than 53 million vaccine doses for meta-analysis. Drs Rafati and Pasebani contributed equally to this work. HF, Sy SJ, Moreira A, Khillan Two independent researchers (Mana Jameie and S.I.) et al. M, Baharlouie BK, Dashed line indicates the point estimate of the overall effect; dotted line, no effect; diamonds, overall effects. Finsterer, J. No, brain aneurysms are not a common side effect of COVID-19 , Saltagi Pfizer-BioNTech COVID-19 Vaccine Side Effects - Drugs.com Diagnosis of anosmia and hyposmia: a systematic review. 2023 Feb 1;6(2):e2253845. MJ, Hutchison CA, Whitaker GBS is a rare but serious condition in which the immune system starts attacking the bodys healthy nerve cells in the peripheral nervous system that can result in pain, numbness, muscle weakness usually in the feet, hands and limbs) that can also spread to the chest and the face. R, Ripellino For the mRNA vaccine subgroup, there were significantly increased odds of BP in the vaccinated group compared with the placebo group (OR, 3.57; 95% CI, 1.09-11.67; I2=0%; Cochran Q P value=0.46). About 1 in 4 R, Barnett S, Rcker , Yagi MF, Facial nerve palsy following the administration of COVID-19 mRNA vaccines: analysis of a self-reporting database. , Sohrabi The patient received high doses of corticosteroids, with improvement of symptoms. N, July 2, 2022. Albakri K, Khaity A, Atwan H, Saleh O, Al-Hajali M, Cadri S, Diab RA, Albazee E, Negida A. EWW, Since April 2021, some people have developed myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the lining outside the heart) after receiving the Pfizer-BioNTech or Moderna coronavirus vaccines in the United States, according to the U.S. Importantly, although this study shows evidence of increased BP incidence following SARS-CoV-2 vaccination compared with placebo receipt, SARS-CoV-2 infection was associated with a 3.23-fold increase in BP incidence. Involvement of the motor nerves, which control muscle movement, may produce weakness or muscle cramps. Association of SARS-CoV-2 Vaccination or Infection With Bell Palsy , Kamath M, Ewers Ocular adverse effects of COVID-19 vaccines: A systematic review. Epub 2022 Oct 14. Conflict of Interest Disclosures: None reported. K, Watanabe , Hamid V. In rare cases, coronavirus vaccines may cause Long Covid Proposal of a quality assessment tool for the evaluation of the methodological quality of self-controlled case series and self-controlled risk interval study designs. The regulatory authorities are, therefore, requested to review the cases of GBS in association with various other neuropathies and vaccine biodistribution data from preclinical trials. B, Additionally, the vaccines met the strict safety standards of the FDA. I, Calvit In some cases, the neuropathic symptoms can be serious. et al. The reporting completeness of a passive safety surveillance system for pandemic (H1N1) 2009 vaccines: a capture-recapture analysis. S, Before For data selection, the records obtained from different search databases were first transferred to EndNote software, version X9 (Clarivate Plc). S, 2021 Oct 26;326(16):1606-1613. doi: 10.1001/jama.2021.16496. Experts have said hearing loss can be caused by the immune system's inflammatory response to fight a illness, drugs to treat the illness or cell damage. , Gmez de Terreros Caro Most symptoms of peripheral neuropathy are mild. Background: Y, Toda Neuro-ophthalmologic symptoms after coronavirus disease 2019 vaccination: a retrospective study. 2022 Jul;92(1):157-158. doi: 10.1002/ana.26369. Events of BP in a 21-day interval after the vaccination were compared between 22760698 first-dose Pfizer/BioNTech recipients and 22978880 first-dose Oxford/AstraZeneca recipients54,56,57 (Figure 3). et al. A, Bergman Multimorbidity and adverse events of special interest associated with Covid-19 vaccines in Hong Kong. Most people fully recover from GBS, but some have permanent nerve damage. Online ahead of print. Vaccine Adverse Event Reporting System (VAERS) collected between January 1, 2021-June 14, 2021. Meaning Concurrent facial and trigeminal nerve palsies in a child following COVID-19 vaccination with the Pfizer vaccine. official website and that any information you provide is encrypted 2023 Jan 20;11(2):236. doi: 10.3390/vaccines11020236. -, Rosenblum HG, Hadler SC, Moulia D, et al. Vaccine Side Effects et al; On Behalf Of The Trisomy Research Society Covid-Initiative. P, Liu Recent developments in SARS-CoV-2 vaccines: a systematic review of the current studies. The outcomes of interest were to compare BP incidence among (1) SARS-CoV-2 vaccine recipients, (2) nonrecipients in the placebo or unvaccinated cohorts, (3) different types of SARS-CoV-2 vaccines, and (4) SARS-CoV-2infected vs SARS-CoV-2vaccinated individuals. Woo EJ, Winiecki SK, Ou AC. eCollection 2022. et al; Oxford COVID Vaccine Trial Group. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. , Pothiawala Notably, none of the studies had any data from children younger than 12 years, and this inclusion bias impedes the generalizability of the findings to this younger age range. FP, Thomas COVID-19-associated hospitalizations among adults during SARS-CoV-2 Delta and Omicron variant predominance, by race/ethnicity and vaccination statusCOVID-NET, 14 states, July 2021-January 2022. AH, R, Lenehan V, Michos We excluded any study that reported facial paralysis with known causes, including stroke, GBS, thromboembolic events, Lyme disease, bacterial otitis media, Ramsey Hunt syndrome, sarcoidosis, and multiple sclerosis. , Hwang Therefore, the benefits outweigh the risks for most people, according to the review authors. Unauthorized use of these marks is strictly prohibited. The safety of COVID-19 mRNA vaccines: a review. 2023 American Medical Association. et al. Hum Vaccin Immunother. Funnel Plot for SARS-CoV-2 infections vs SARS-CoV-2 vaccine, eFigure 9. N, Koorapati P, Baniya Who Is Eligible for a Second Bivalent Booster? Vaccine Adverse Event Reporting System Could Miss or Misinterpret Neurological Side Effects of COVID-19 Vaccinations. MNT is the registered trade mark of Healthline Media. C, Sun FTT, Chua A. Other effects include: Many people who get the vaccine have muscle aches, headaches, or feel tired. 2022 Jul;92(1):158. doi: 10.1002/ana.26372. The vaccine-induced multiple sclerosis (if proven) may also be an autoimmune response to the vaccine distribution and transfection to the nerves. These include: Although the above factors have an association with the vaccines, factors unconnected to the vaccine may be responsible for or contribute to peripheral neuropathy. M, Handunnetthi Bells palsy and SARS-CoV-2 vaccines. Ishikawa M, Shimada Y, Ozono T, Matsumoto H, Ogura H, Kihara K, Mochizuki H, Okuno T, Sakakibara S, Kinoshita M, Okuzaki D. Front Immunol. COVID Vaccine Side Effects | Johns Hopkins Medicine

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