2. providers are skilled and can implement it quickly. It is done by compressing the chest with both hands. 2. If cardiac arrest develops as the result of cocaine toxicity, there is no evidence to suggest deviation from standard BLS and ALS guidelines, with specific treatment strategies used in the postcardiac arrest phase as needed if there is evidence of severe cardiotoxicity or neurotoxicity. This concern is especially pertinent in the setting of asphyxial cardiac arrest. 1. 2. This topic last received formal evidence review in 2010.10, Local anesthetic overdose (also known as local anesthetic systemic toxicity, or LAST) is a life-threatening emergency that can present with neurotoxicity or fulminant cardiovascular collapse.1,2 The most commonly reported agents associated with LAST are bupivacaine, lidocaine, and ropivacaine.2, By definition, LAST is a special circumstance in which alternative approaches should be considered in addition to standard BLS and ALS. These include mechanical CPR, impedance threshold devices (ITD), active compression-decompression (ACD) CPR, and interposed abdominal compression CPR. Atrial flutter is an SVT with a macroreentrant circuit resulting in rapid atrial activation but intermittent ventricular response. IV infusion of epinephrine may be considered for post-arrest shock in patients with anaphylaxis. These guidelines are not meant to be comprehensive. Release the pressure. In patients who remain comatose after cardiac arrest, we recommend that neuroprognostication be delayed until adequate time has passed to ensure avoidance of confounding by medication effect or a transiently poor examination in the early postinjury period. In unmonitored cardiac arrest, it is reasonable to provide a brief prescribed period of CPR while a defibrillator is being obtained and readied for use before initial rhythm analysis and possible defibrillation. Emergent coronary angiography is reasonable for select (eg, electrically or hemodynamically unstable) adult patients who are comatose after OHCA of suspected cardiac origin but without ST-segment elevation on ECG. The 2019 focused update on ACLS guidelines addressed the use of advanced airways in cardiac arrest and noted that either bag-mask ventilation or an advanced airway strategy may be considered during CPR for adult cardiac arrest in any setting.1 Outcomes from advanced airway and bag-mask ventilation interventions are highly dependent on the skill set and experience of the provider (Figure 7). For a victim with a tracheal stoma who requires rescue breathing, either mouth-to-stoma or face mask (pediatric preferred) tostoma ventilation may be reasonable. This involves the cannulation of a large vein and artery and initiation of venoarterial extracorporeal circulation and membrane oxygenation (ECMO) (Figure 8). Limited evidence from case reports and case series demonstrates transient increases in aortic and intracardiac pressure with the use of cough CPR at the onset of tachyarrhythmias or bradyarrhythmias in conscious patients. 3. For cardiotoxicity and cardiac arrest from severe hypomagnesemia, in addition to standard ACLS care, IV magnesium is recommended. Vasopressor medications during cardiac arrest. EMS systems that perform prehospital intubation should provide a program of ongoing quality improvement to minimize complications and track overall supraglottic airway and endotracheal tube placement success rates. 2. 2. Multiple case reports have observed intracranial placement of nasopharyngeal airways in patients with basilar skull fractures. Peer reviewer feedback was provided for guidelines in draft format and again in final format. Either bag-mask ventilation or an advanced airway strategy may be considered during CPR for adult cardiac arrest in any setting depending on the situation and skill set of the provider. In patients without an advanced airway, it is reasonable to deliver breaths either by mouth or by using bag-mask ventilation. 2. This begins with opening the airway followed by delivery of rescue breaths, ideally with the use of a bag-mask or barrier device. Postcardiac arrest care is a critical component of the Chain of Survival and demands a comprehensive, structured, multidisciplinary system that requires consistent implementation for optimal patient outcomes. Treatment of atrial fibrillation/flutter depends on the hemodynamic stability of the patient as well as prior history of arrhythmia, comorbidities, and responsiveness to medication. 1. Some treatment recommendations involve medical care and decision-making after return of spontaneous circulation (ROSC) or when resuscitation has been unsuccessful. 2. Survival and recovery from adult cardiac arrest depend on a complex system working together to secure the best outcome for the victim. No shock waveform has proved to be superior in improving the rate of ROSC or survival. Recommendations 1 and 2 are supported by the 2020 CoSTR for ALS.22 Recommendations 3 and 4 last received formal evidence review in 2010.20. A number of key components have been defined for high-quality CPR, including minimizing interruptions in chest compressions, providing compressions of adequate rate and depth, avoiding leaning on the chest between compressions, and avoiding excessive ventilation.1 However, controlled studies are relatively lacking, and observational evidence is at times conflicting. Advanced airway (or advanced airway management) is a practice used by medical professionals to support breathing such as an endotracheal tube, a laryngeal mask airway, or an esophageal-tracheal combitube. Based on the protocols used in clinical trials, it is reasonable to administer epinephrine 1 mg every 3 to 5 min for cardiac arrest. 3. receiving CPR with ventilation? 2. Can artifact-filtering algorithms for analysis of ECG rhythms during CPR in a real-time clinical setting For . 1. What defines optimal hospital care for patients with ROSC after cardiac arrest is not completely known, but there is increasing interest in identifying and optimizing practices that are likely to improve outcomes. We suggest recording EEG in the presence of myoclonus to determine if there is an associated cerebral correlate. 3. However, an oral airway is preferred because of the risk of trauma with a nasopharyngeal airway. As more and more centers and EMS systems are using feedback devices and collecting data on CPR measures such as compression depth and chest compression fraction, these data will enable ongoing updates to these recommendations. The head tiltchin lift has been shown to be effective in establishing an airway in noncardiac arrest and radiological studies. 4. 4. If so, what dose and schedule should be used? The initial phases of resuscitation once cardiac arrest is recognized are similar between lay responders and healthcare providers, with early CPR representing the priority. 1. Recommendations for the treatment of cardiac arrest due to hyperkalemia, including the use of calcium and sodium bicarbonate, are presented in Electrolyte Abnormalities. 1. Cardiopulmonary Resuscitation During the COVID-19 Pandemic What is the optimal energy needed for cardioversion of atrial fibrillation and atrial flutter? 3. It may be reasonable to charge a manual defibrillator during chest compressions either before or after a scheduled rhythm analysis. Technologies are now in development to diagnose the underlying cardiac rhythm during ongoing CPR and to derive prognostic information from the ventricular waveform that can help guide patient management. In a tiered ALS- and BLS-provider system, the use of the BLS TOR rule can avoid confusion at the scene of a cardiac arrest without compromising diagnostic accuracy. The dedicated rescuer who provides manual abdominal compressions will compress the abdomen midway between the xiphoid and the umbilicus during the relaxation phase of chest compression. However, these case reports are subject to publication bias and should not be used to support its effectiveness. Prompt treatment of cardiac glycoside toxicity is imperative to prevent or treat life-threatening arrhythmias. 1-800-AHA-USA-1 The value of VF waveform analysis to guide the acute management of adults with cardiac arrest has not been established. In the supine position, aortocaval compression can occur for singleton pregnancies starting at approximately 20 weeks of gestational age or when the fundal height is at or above the level of the umbilicus. Fist (or percussion) pacing is the delivery of a serial, rhythmic, relatively low-velocity impact to the sternum by a closed fist.1 Fist pacing is administered in an attempt to stimulate an electric impulse sufficient to cause myocardial depolarization. Unlike most other cardiac arrests, these patients typically develop cardiac arrest in a highly monitored setting such as an ICU, with highly trained staff available to perform rescue therapies. 2. Give 1 breath every 6 seconds (10 breaths/min) CPR Compression Rate. It remains to be tested whether patients with signs of shock benefit from emergent coronary angiography and PCI. Hydroxocobalamin and 100% oxygen, with or without sodium thiosulfate, can be beneficial for cyanide poisoning. -Enough to make the victim's chest rise. Quantitative waveform capnography - If Petco 2 <10 mm Hg, attempt to improve CPR quality. Survival with a favorable neurological outcome (Cerebral Performance Category 12) was higher in the group treated with 33C. AEDs are highly accurate in their detection of shockable arrhythmias but require a pause in CPR for automated rhythm analysis. Interposed abdominal compression CPR may be considered during in-hospital resuscitation when sufficient personnel trained in its use are available. Drug administration by central venous access (by internal jugular or subclavian vein) achieves higher peak concentrations and more rapid circulation times than drugs administered by peripheral IV do, Endotracheal drug administration is regarded as the least-preferred route of drug administration because it is associated with unpredictable (but generally low) drug concentrations. 1. These recommendations are supported by the 2019 AHA Focused Update on Advanced Cardiovascular Life Support: Use of Advanced Airways, Vasopressors, and Extracorporeal CPR During Cardiac Arrest: An Update to the AHA Guidelines for CPR and Emergency Cardiovascular Care.12. Synchronized cardioversion or drugs or both may be used to control unstable or symptomatic regular narrow-complex tachycardia. This makes it difficult to plan the next step of care and can potentially delay or even misdirect drug therapies if given empirically (blindly) based on the patients presumed, but not actual, underlying rhythm. It may be reasonable to administer IV lipid emulsion, concomitant with standard resuscitative care, to patients with local anesthetic systemic toxicity (LAST), and particularly to patients who have premonitory neurotoxicity or cardiac arrest due to bupivacaine toxicity. Unfortunately, different studies define highly malignant EEG differently or imprecisely, making use of this finding unhelpful. This time delay is a consistent issue in OHCA trials. When providing rescue breaths, it may be reasonable to give 1 breath over 1 s, take a regular (not deep) breath, and give a second rescue breath over 1 s. 4. It may be reasonable to consider administration of epinephrine during cardiac arrest according to the standard ACLS algorithm concurrent with rewarming strategies. Epidemiological data suggest that risk factors for This topic was previously reviewed by ILCOR in 2015. Do neuroprotective agents improve favorable neurological outcome after arrest? 2. Perimortem cesarean delivery (PMCD) at or greater than 20 weeks uterine size, sometimes referred to as resuscitative hysterotomy, appears to improve outcomes of maternal cardiac arrest when resuscitation does not rapidly result in ROSC (Figure 15).1014 Further, shorter time intervals from arrest to delivery appear to lead to improved maternal and neonatal outcomes.15 However, the clinical decision to perform PMCDand its timing with respect to maternal cardiac arrestis complex because of the variability in level of practitioner and team training, patient factors (eg, etiology of arrest, gestational age), and system resources. Step 5. There are no data evaluating the use of antidotes to digoxin overdose specifically in the setting of cardiac arrest. Step 4. Hemodynamically unstable patients with atrial fibrillation or atrial flutter with rapid ventricular response should receive electric cardioversion. This topic last received formal evidence review in 2010.22. These deliver different peak currents even at the same programmed energy setting, making comparisons of shock efficacy between devices challenging. The usefulness of S100 calcium-binding protein (S100B), Tau, neurofilament light chain, and glial fibrillary acidic protein in neuroprognostication is uncertain. It may be reasonable to use audiovisual feedback devices during CPR for real-time optimization of CPR performance. This Recovery link highlights the enormous recovery and survivorship journey, from the end of acute treatment for critical illness through multimodal rehabilitation (both short- and long-term), for both survivors and families after cardiac arrest. In patients presenting with acute symptomatic bradycardia, evaluation and treatment of reversible causes is recommended. IV antiarrhythmic medications may be considered in stable patients with wide-complex tachycardia, particularly if suspected to be VT or having failed adenosine. The same anticonvulsant regimens used for the treatment of seizures caused by other etiologies may be considered for seizures detected after cardiac arrest. A 2017 ILCOR systematic review concluded that although the evidence from observational studies supporting the use of bundles of care including minimally interrupted chest compressions was of very low certainty (primarily unadjusted results), systems already using such an approach may continue to do so. Given the potential for the rapid development of oropharyngeal or laryngeal edema, immediate referral to a health professional with expertise in advanced airway placement, including surgical airway management, is recommended. Part 4: Adult Basic Life Support | Circulation At least 1 retrospective study on ECMO use for patients with cardiac arrest or refractory shock in the setting of drug toxicity has reported improved outcomes. Artifact-filtering and other innovative techniques to disclose the underlying rhythm beneath ongoing CPR can surmount these challenges and minimize interruptions in chest compressions while offering a diagnostic advantage to better direct therapies. 4. Determining the utility of such physiological monitoring or diagnostic procedures is important. Studies on push-dose epinephrine for bradycardia specifically are lacking, although limited data support its use for hypotension. If atropine is ineffective, either alternative agents to increase heart rate and blood pressure or transcutaneous pacing are reasonable next steps. Despite steady improvement in the rate of survival from IHCA, much opportunity remains. In addition, it may be helpful for providers to master an advanced airway strategy as well as a second (backup) strategy for use if they are unable to establish the first-choice airway adjunct. IV lidocaine, amiodarone, and measures to treat myocardial ischemia may be considered to treat polymorphic VT in the absence of a prolonged QT interval. A study in critically ill patients who required ventilatory support found that bag-mask ventilation at a rate of 10 breaths per minute decreased hypoxic events before intubation. In adult cardiac arrest, total preshock and postshock pauses in chest compressions should be as short as possible. *Red Dress DHHS, Go Red AHA ; National Wear Red Day is a registered trademark. Neuroimaging may be helpful after arrest to detect and quantify structural brain injury. Several RCTs have compared a titrated approach to oxygen administration with an approach of administering 100% oxygen in the first 1 to 2 hours after ROSC. Airway management during cardiac arrest usually commences with a basic strategy such as bag-mask ventilation. OHCA is a resource-intensive condition most often associated with low rates of survival. Does avoidance of hyperoxia in the postarrest period lead to improved outcomes? 5. This cause of death is especially prominent in those with OHCA but is also frequent after IHCA.1,2 Thus, much of postarrest care focuses on mitigating injury to the brain. With respect to timing, for cardiac arrest with a nonshockable rhythm, it is reasonable to administer epinephrine as soon as feasible. It is reasonable to immediately resume chest compressions after shock delivery for adults in cardiac arrest in any setting. A systematic review of the literature identified 5 small prospective trials, 3 retrospective studies, and multiple case reports and case series with contradictory results. The combitube has two separate balloons that must be inflated and two separate ports. Are NSE and S100B helpful when checked later than 72 h after ROSC? 3. EEG patterns that were evaluated in the 2020 ILCOR systematic review include unreactive EEG, epileptiform discharges, seizures, status epilepticus, burst suppression, and highly malignant EEG. As an example, there is insufficient evidence concerning the cardiac arrest bundle of care with the inclusion of heads-up CPR to provide a recommendation concerning its use.2 Further investigation in this and other alternative CPR techniques is best explored in the context of formal controlled clinical research. Acknowledging these data, the use of mechanical CPR devices by trained personnel may be beneficial in settings where reliable, high-quality manual compressions are not possible or may cause risk to personnel (ie, limited personnel, moving ambulance, angiography suite, prolonged resuscitation, or with concerns for infectious disease exposure). 4. OT indicates occupational therapy; PT, physical therapy; PTSD, posttraumatic stress disorder; and SLP, speech-language pathologist, Severe accidental environmental hypothermia (body temperature less than 30C [86F]) causes marked decrease in both heart rate and respiratory rate and may make it difficult to determine if a patient is truly in cardiac arrest. Observational studies of fibrinolytic therapy for suspected PE were found to have substantial bias and showed mixed results in terms of improvement in outcomes. Available hemodynamic monitoring modalities in conjunction with manual pulse detection provide an opportunity to confirm myocardial capture and adequate cardiac function. Commercially available defibrillators either provide fixed energy settings or allow for escalating energy settings; both approaches are highly effective in terminating VF/VT. Emergent electric cardioversion and defibrillation are highly effective at terminating VF/VT and other tachyarrhythmias. Opioid overdoses deteriorate to cardiopulmonary arrest because of loss of airway patency and lack of breathing; therefore, addressing the airway and ventilation in a periarrest patient is of the highest priority. Torsades de pointes is a form of polymorphic VT that is associated with a prolonged heart ratecorrected QT interval when the rhythm is normal and VT is not present. Patients with accidental hypothermia often present with marked CNS and cardiovascular depression and the appearance of death or near death, necessitating the need for prompt full resuscitative measures unless there are signs of obvious death. On CT, brain edema can be quantified as the GWR, defined as the ratio between the density (measured as Hounsfield units) of the gray matter and the white matter. Coronary artery disease (CAD) is prevalent in the setting of cardiac arrest.14 Patients with cardiac arrest due to shockable rhythms have demonstrated particularly high rates of severe CAD: up to 96% of patients with STEMI on their postresuscitation ECG,2,5 up to 42% for patients without ST-segment elevation,2,57 and 85% of refractory out-of-hospital VF/VT arrest patients have severe CAD.8 The role of CAD in cardiac arrest with nonshockable rhythms is unknown. The ITD is a pressure-sensitive valve attached to an advanced airway or face mask that limits air entry into the lungs during the decompression phase of CPR, enhancing the negative intrathoracic pressure generated during chest wall recoil and improving venous return and cardiac output during CPR. These recommendations are supported by the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/AHA Task Force on Practice Guidelines and the Heart Rhythm Society18 as well as the focused update of those guidelines published in 2019.2, These recommendations are supported by 2014 AHA, American College of Cardiology, and Heart Rhythm Society Guideline for the Management of Patients With Atrial Fibrillation18 as well as the focused update of those guidelines published in 2019.2. Two studies that included patients enrolled in the AHA Get With The GuidelinesResuscitation registry reported either no benefit or worse outcome from TTM. This topic was last reviewed in 2010 and identified 2 randomized trials, interposed abdominal compression CPR performed by trained rescuers improved short-term survival. All of these activities require organizational infrastructures to support the education, training, equipment, supplies, and communication that enable each survival. Normal brain has a GWR of approximately 1.3, and this number decreases with edema. Which patients with cardiac arrest due to suspected pulmonary embolism benefit from emergency In patients who remain comatose after cardiac arrest, we recommend that neuroprognostication involve a multimodal approach and not be based on any single finding. ECPR indicates extracorporeal cardiopulmonary resuscitation. An analysis of data from the AHAs Get With The Guidelines-Resuscitation registry showed higher likelihood of ROSC (odds ratio, 1.22; 95% CI, 1.041.34; Studies have reported that enough tidal volume to cause visible chest rise, or approximately 500 to 600 mL, provides adequate ventilation while minimizing the risk of overdistension or gastric insufflation. Recommendation 1 is supported by the 2019 focused update on ACLS guidelines.3 Recommendation 2 last received formal evidence review in 2015.4 Recommendation 3 is supported by the 2020 CoSTR for ALS.11, These recommendations are supported by the 2015 Guidelines Update24 and a 2020 evidence update.11. A more detailed approach to rhythm management is found elsewhere.13, This topic last received formal evidence review in 2010.17, Polymorphic VT refers to a wide-complex tachycardia of ventricular origin with differing configurations of the QRS complex from beat to beat. Nonconvulsive seizures are common after cardiac arrest. or sooner if fatigued. 2. Case reports support the use of ECMO for patients with refractory shock due to TCA toxicity. If an experienced sonographer is present and use of ultrasound does not interfere with the standard cardiac arrest treatment protocol, then ultrasound may be considered as an adjunct to standard patient evaluation, although its usefulness has not been well established. This topic last received formal evidence review in 2015.7. When performed with other prognostic tests, it may be reasonable to consider status myoclonus that occurs within 72 h after cardiac arrest to support the prognosis of poor neurological outcome. In the 2020 ILCOR systematic review, no randomized trials were identified addressing the treatment of cardiac arrest caused by confirmed PE. 6. Chest compressions are the most critical component of CPR, and a chest compressiononly approach is appropriate if lay rescuers are untrained or unwilling to provide respirations.
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